Biospring GmbH Frankfurt, Main, Germany

About Biospring GmbH:

BioSpring provides pre-clinical and commercial-scale oligonucleotide manufacturing capabilities for therapeutics use and preclinical mRNA capability. They support early-stage programs with small and intermediate-scale production and late-stage/commercial programs with cGMP manufacturing up to hundreds of kilograms of API quantities.

Service Offerings:

• Oligonucleotide manufacturing
• Analytical Development
• Analytical Validation
• Commercial API manufacturing
• GMP & Pre-Clinical Manufacturing
• Oligonucleotides for Diagnostics
• Oligonucleotides for R&D
• Broad range of synthesis chemistries and modifications
• Broad spectrum of post-synthetic conjugation techniques
• Terminal GalNAc conjugates & PEGylation
• Long and complex oligonucleotides (e.g.
• single guide RNA for CRISPR/Cas9)
• Customized processes
• Specific manufacturing strategies for in vivo applications
• Lead identification support
• Development of new chemistries
• In-solution chemistries for conjugation

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