Trilink offers a selection of Modified DNA, RNA, and Specialty oligonucleotides and scales up of nucleic acids, NTPs, and mRNA capping analogs. Trilink collaborates with customers from discovery to commercialization. They manufacture non-coding RNAs and provide tailored synthesis at milligram to multigram scales, with lengths ranging from a few hundred nucleotides to greater than 10 kilobases.
TriLink has an extensive collection of modified nucleotides that can modulate innate immune recogn...ition to maximize activity for a specific application. Trilink's proprietary CleanCap® technology allows for co-transcriptional capping.
Trilink offers numerous post-transcriptional modifications, including DNase and phosphatase treatments, enzymatic capping, and polyadenylation. Additionally, you can select from a variety of purification options, including silica gel purification, liquid chromatography isolation, and high-performance liquid chromatography for your mRNA production
Service Offerings:
sgRNA
Randomers
Molecular beacons
siRNA
TINA modified Oligos
OEM program that includes research-grade and GMP manufacturing.
TriLink has an amazing facility and they provide products that are transofrmative for mRNA manufacturing. My interactions with their team have always been excellent and they have incredible employees. When we encountered snags during batches, we were... always able to resolve them amicably and they were always willing to do what's right. My only dissapointment is that they do not appear to intend to do manufacturing of product that is suitable for anything past phase 1. This makes them difficult to choose as a partner for any project that is likely going into clinic.
The quality of their research grade mRNA appears to have increased considerably as well. They have been flexible when asked to deviate from normal opperations. Overall, a great partner to work with.
The quality of their research grade mRNA appears to have increased considerably as well. They have been flexible when asked to deviate from normal opperations. Overall, a great partner to work with.